About CaL-Threonate+

What is Calcium L-threonate?

Calcium L-threonate is a compound designed for the treatment of bone disease. L-threonic acid is an active metabolite of vitamin C which had been shown to have an ability in enhancing the bioavailability of minerals, such as calcium. It is well known that vitamin C is a marker for osteoblast formation and has been shown to stimulate procallagen and enhance collagen synthesis (Morton et al. 2001; Hall et al. 1998; Franceschi & Lyer 1992).

How can L-threonate helps in bone remodeling?

In an in vitro study, calcium L-threonate was one of the metabolites that was suggested to influence the formation of mineralized nodules and collagenous proteins (Rowe et al. 1999).

In rabbit model study, L-threonate, specifically calcium L-threonate was found to inhibit the bone resorption of osteoclasts measured by the levels of type I collagen C-telopeptide (CTx) (He et al. 2005).

Calcium L-threonate was shown to have stimulation effects on proliferation rate, ALP activity and mineralization nodules formation of osteoblasts cultured in vitro and the effect was stronger than calcium gluconate or calcium chloride. Therefore, calcium L-threonate is a powerful compound in enhancing bone formation, while at the same time inhibiting the bone resorption of osteoclasts.

What is hydrolysed collagen?

Hydrolysed collagen is derived from bone and cartilage. It composed of amino acids which are essential in building collagen and tissues in human body.

Studies have shown that orally administered collagen hydrolysate were absorbed in intestine, accumulated in cartilage and increased the synthesis of extracellular matrix macromolecules by chondrocytes, therefore it is helpful for patients with joint disorder, specifically osteoarthritis (Bello et al. 2006). Further, a 24-week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain showed that the use of collagen hydrolysate significantly reduced pain, support joint health and possibly reduce the risk of joint deterioration (Clark et al. 2008).

What is γ-oryzanol?

It is rice bran oil extracted from the outer brown layer of rice. Rice bran oil is high in monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), specifically omega-6 (38%). A 10-week intervention study conducted in Thailand showed that rice bran oil is effective in lowering total cholesterol and LDL-C (Utarwuthipong et al. 2009). In addition, the US Nurses’ Health Study (n=80,082 women) have reported a 42% reduction in relative risk for cardiovascular disease when PUFA was substituted for saturated fat in diets (Hu et al. 1997).

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